Blue Methylene – Research
- Aging
Methylene blue is good for the skin. MB increases mitochondrial function and reduces oxidative stress – both of which independently improve the appearance of skin. MB has even been used to treat psoriasis, an autoimmune disease. By increasing collagen and elastin production, methylene blue gives skin a more youthful appearance.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699482/ - Depression
Methylene blue can have a “strong” effect against symptoms of depression. This is because it can increase levels of norepinephrine, serotonin and dopamine in the brain, preventing the breakdown of these neurotransmitters. MB can also regulate anxiety and bipolar disorder, which are closely related to depression. It is not recommended to take MB at the same time as other antidepressants.
https://pubmed.ncbi.nlm.nih.gov/3555627/
https://pubmed.ncbi.nlm.nih.gov/31144270/ - Lyme disease and co-infections
Although most patients with Lyme disease are cured after 2-4 weeks of antibiotics, up to 20% of patients are not cured as quickly. Methylene blue is a potential alternative for people in whom antibiotics have failed. In the lab, methylene blue effectively killed antibiotic-resistant Lyme disease bacteria. Combining methylene blue with certain antibiotics increases the effectiveness of antibiotics to fight Lyme disease. Studies have also shown that combining methylene blue with antibiotics is more effective than antibiotics alone in treating Bartonella infections.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311795/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149919/ - Alzheimer’s disease, Parkinson’s disease
Methylene blue can help prevent Alzheimer’s disease, Parkinson’s disease and mild cognitive disorders. MB reduces oxidative damage to brain cells – contributing to neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Numerous studies indicate that MB is “a promising neuroprotective intervention for both motor and non-motor” symptoms of Parkinson’s disease. MB is not a panacea for neurotoxicity and neurodegenerative diseases, but methylene blue boasts decades of recorded neuroprotective benefits.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992595/
https://pubmed.ncbi.nlm.nih.gov/36804486/ - Methemoglobinemia
This is a blood disorder that can cause headaches, dizziness, nausea or skin discoloration. Methylene blue is an FDA-approved treatment for this mainly genetic disorder, which can turn the color of the blood chocolate-colored. Certain drugs or chemicals can also cause high levels of methemoglobin. MB converts the iron in hemoglobin into ferrous iron, thus treating the condition. The most common use of methylene blue is to treat methemoglobinemia, for which a doctor may prescribe MB injections.
https://www.ncbi.nlm.nih.gov/books/NBK537317/ - Nail fungus
Methylene blue can help fungal infections, similar to bacterial infections. A 2014 study shows that when combined with red LED light, methylene blue effectively treats “distal and lateral nail fungus”.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938382/ - Methylene blue and photodynamic therapy in the treatment of cancer and non-cancer diseases.
https://pubmed.ncbi.nlm.nih.gov/25048768/ - Methylene Blue in the treatment of sepsis (septicemia).
https://journals.sagepub.com/doi/10.1177/0885066606290671 - Methylene Blue in the treatment of bacterial and coronavirus infections in vivo and in vitro.
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-023-03018-1 - Methylene Blue increases the functionality of neuronal connections of the brain in the resting state.
https://ncbi.nlm.nih.gov/pmc/articles/PMC5018244/ - Methylene Blue and nitric oxide , treatment of sepsis.
https://pubmed.ncbi.nlm.nih.gov/32631574/ - Methylene Blue treats cerebral hypoperfusion, a risk factor for Alzheimer’s disease.
https://pubmed.ncbi.nlm.nih.gov/25079810/ - Methylene Blue and liver cirrhosis.
https://semanticscholar.org/paper/Methylene-Blue%3A-Revisited-Ginimuge-Jyothi/8419706a0d3e366faf7753bf7cfa160759daa233 - Methylene Blue accelerates glutathione oxidation, improving redox balance, detoxification and cysteine transport.
https://sciencedirect.com/science/article/pii/S0021925818957170 - Bethylene Blue – topical anti-aging effect.
https://t.co/NumESMOuiU - Methylene Blue, topical protection against UV damage.
https://t.co/MLeu9GdzCM - Oral Methylene Blue reduces ROS and promotes longevity.
https://t.co/Ay4XGVTIe9 - Methylene Blue shows signs of neuroprotection.
https://t.co/bkXHFSNgCp - Methylene Blue improves memory and neuroprotection.
https://pubmed.ncbi.nlm.nih.gov/22067440/ - Methylene Blue pulling people off ventilators during pandemics.
https://t.co/MC5no5TF6s - Methylene Blue shows protection against stroke damage.
https://t.co/f2XdPfhnOa - Methylene Blue shows protection against TBI.
https://t.co/1SQtqqOmlh - Methylene Blue shows memory improvement (animal study).
https://pubmed.ncbi.nlm.nih.gov/25079810/ - Methylene Blue showing promise in fighting Alzheimer’s disease.
https://t.co/ZlimG5HZfn - Another study on Alzheimer’s disease.
https://pubmed.ncbi.nlm.nih.gov/20463399/ - Neuropsychiatric benefits of Methylene Blue.
https://t.co/tHubh3bXme - Methylene Blue in the fight against depression.
https://pubmed.ncbi.nlm.nih.gov/3555627/ - Methylene Blue with near-infrared light to protect against neurodegeneration.
https://t.co/JYiSrEmYaA - Methylene Blue causes mitochondrial repair through mitophagy.
https://t.co/VZJhjMKu5p - Methylene Blue reduces white matter damage after stroke.
https://t.co/8PJWNtYJ1X - Methylene Blue and improves recovery after TBI.
https://t.co/urhkY0tz7u - Methylene Blue to fight neuroinflammation.
https://t.co/v39uR1md7l - Methylene Blue reduces the oxidative effects of ethanol.
https://pubmed.ncbi.nlm.nih.gov/8274146/ - Methylene Blue to increase mitochondrial oxidative phosphorylation and inhibit tumor proliferation. https://pubmed.ncbi.nlm.nih.gov/26603930/
- Methylene Blue improves NAD/NADH and pAMPK/AMPK ratio.
https://t.co/eBeHpgb0F1 - Methylene Blue prevents tau-related neurotoxicity.
https://t.co/65ghZ2qzgy - Methylene Blue helps autophagy and apoptosis.
https://t.co/DsbpeLCRNc - Methylene Blue improves short-term memory.
https://t.co/NL0xgXr1IO - Methylene Blue increases functional connectivity between brain regions associated with working memory.
https://t.co/U2ErG3iK71 - Methylene Blue improves cardiac function in diabetics.
https://pubmed.ncbi.nlm.nih.gov/28303408/ - Methylene Blue shows activity against brain diseases, as well as viral diseases.
https://t.co/0byw1UV7sq - History of the use of Methylene Blue and newly discovered benefits.
https://pubmed.ncbi.nlm.nih.gov/27576224/ - Methylene Blue improves memory and neuroprotection.
https://t.co/okr9TXoExU - Clinical trial against manic-depressive psychosis.
https://pubmed.ncbi.nlm.nih.gov/3091097/ - Methylene Blue ameliorates damage caused by c 19.
https://t.co/hnQrFb9xTh - Methylene Blue and light induced neuroprotection. https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-020-00197-z