Disclaimer: The content published on our website regarding methylene blue consists solely of personal observations and thoughts. It should not be considered as health, medical, or any other type of professional advice. Each reader should independently analyze the available information, draw their own conclusions, and, if necessary, consult with an appropriate specialist.
Methylene Blue Guide
“Imagine substance so powerful it could sharpen your mind energize your cells and maybe even help you live a longer life by giving life back to the oxygen contained inside your cells.”
Gary Brecka
This is how methylene blue works.
Memory and concentration
The neuroprotective properties of methylene blue are well known. It improves mitochondrial activity, resulting in increased mental clarity, stronger focus and better memory. Methylene blue can give your brain a much-needed boost, whether you’re a professional, a student, or just trying to stay mentally fit.
Mitochondrial support
Methylene blue provides cells with efficient energy production by supporting mitochondrial respiration at the cellular level. This translates into better physical endurance, less fatigue and an overall feeling of energy.
Anti-aging
Methylene blue has powerful antioxidant properties that help protect cells from oxidative stress and prevent damage. Frequent use can help maintain youthful skin and strong health by slowing the aging process.
Biohacking and the effects of methylene blue on health and the human body
Methylene blue is gaining increasing importance in biohacking – a field that aims to improve bodily functions using advanced techniques and substances that promote performance, concentration and health at the cellular level. One of the most interesting properties of this compound is its effect on mitochondria, the structures responsible for energy production in cells.
Thanks to its strong antioxidant properties and its ability to support mitochondria, methylene blue is used by people seeking to improve their health and quality of life.
Due to its easy permeability into cells, methylene blue can accept and donate electrons, making it extremely effective in neutralizing free radicals – reactive oxygen species that have a negative impact on the body. This ability to fight oxidative stress is crucial in protecting the mitochondria, and therefore also in preventing the aging process and the development of diseases. By improving mitochondrial function, methylene blue has a positive effect on physical performance, concentration and overall well-being. As cellular “power plants”, mitochondria are the basis of metabolic processes, and damage to them leads to a decline in energy production and increases the risk of neurodegenerative diseases such as Alzheimer’s, Parkinson’s and multiple sclerosis.
A 2008 clinical trial showed that Alzheimer’s patients taking methylene blue improved significantly. Thanks to its properties, it may protect the mitochondria and support them in fighting the symptoms of neurodegeneration. Methylene blue shows anti-aging effects, benefiting brain and overall body health.
Skin condition
By improving mitochondrial function and reducing oxidative stress, methylene blue improves skin condition. It has also been involved in the treatment of psoriasis, an autoimmune disease. It also gives younger-looking skin by increasing collagen and elastin production.
Mental health
Studies have shown that methylene blue can benefit emotional well-being and mood. It can help reduce anxiety and symptoms of depression, resulting in a more balanced and positive mental state.
Versatility
Methylene blue has a wide range of medicinal uses, including the treatment of methemoglobinemia, and has been used for years as a proven antimalarial drug. Because of its well-established safety and efficacy, it is a reliable option in a variety of therapeutic contexts.
How to get started?
First and foremost, it should be noted that methylene blue is not recognized as a dietary supplement in the European Union. As part of expanding our knowledge, we analyzed information regarding its dosage, drawing from publicly available sources provided by scientists, doctors, and users. We’ve come across disturbing online posts indicating that some people are reaching for random methylene blue and consuming it. This way, one can seriously harm themselves. We believe it is important for users to have full access to information about methylene blue, including its properties, effectiveness, and potential side effects, so they can make an informed decision about its use.
Doses around 5-10 mg per day are often mentioned in the context of mitochondrial support and antioxidant activity. For a 1% solution of methylene blue, each drop contains 0.5 mg of the substance. To reach a dose of 10 mg, use 20 drops.
You can start by adding 10 drops (5 mg) to a glass of water or juice in the morning and 10 drops (5 mg) before bed. This dose can be used for a week, for example, and if you tolerate this regimen well and want to increase the dose, you can raise it to 20 mg a day.
To obtain a dose of 20 mg per day, add 20 drops (10 mg) to a glass of water or juice and consume in the morning, and then repeat this action in the evening before bedtime. At the end of the second week, the dose can be increased to 30 mg per day, if needed. This regimen can be continued until the target dose is reached.
Methylene blue’s potential to slow skin aging: The key to longevity
How do you feel after taking methylene blue?
1 hour after taking
a noticeable increase in energy
2 hours after taking
brain fog completely disappears, thoughts are clear and sharp as never before
3 hours after taking,
focus is at its highest level, no effort is needed to maintain it
For the insightful
Looking for information for ourselves, we dug all over the foreign Internet. It’s a fresh topic in Poland, so most of the articles and research results are in English. Here’s an index of what we found particularly interesting – from research on Lyme disease and co-infections, Alzheimer’s disease, Parkinson’s disease, fungal diseases and the importance of methylene blue in the treatment of bacterial and coronaviral infections in vivo and in vitro – to protection against stroke:
We have also prepared a summary of the guide to methylene blue:
Types of methylene blue
Only the pharmaceutical grade is suitable for use, which must have a certification of purity above 99%. The chemical grade is often advertised as having 98% purity, but you won’t receive any certificate for that, as the requirement is not a specific number but a defined purity range, i.e., 85% – 99%. When attempting to purchase methylene blue in Poland, no other manufacturer of second-grade reagents has provided tests that specify exact purity and detailed heavy metal content, which in fact can constitute up to 15%.
The two websites from which we purchased methylene blue, confirmed by testing and additionally verified by an external laboratory, are:
- Blue Zone: blue-zone.org – ships from Poland and offers promotional deals on multi-packs.
- Meraki: merakimedicinal.com – we ordered from them initially, but unfortunately, the shipping time to Poland takes over a month, and there are additional customs fees.
Blue Zone and Meraki Medicinal offer tested methylene blue that is free from contaminants such as formaldehyde. Other methylene blue products available on the market may be preserved with formaldehyde, and the lower the price, the higher the likelihood that this is the case.
Methylene blue – history
Chemically it is known as methylthionine chloride and was developed in 1876 as a dye for textiles, while its medical properties began to be studied in 1891. It is on the World Health Organization’s (WHO) list of essential medicines.
Contraindications, side effects
There is a wealth of research on the safety and effectiveness of methylene blue, but its use should be approached with caution. In small amounts, methylene blue poses no risk to most people; however, certain groups—including those taking specific antidepressants, opioids, or antihistamines (due to the potential for dangerously elevating serotonin levels), as well as pregnant or breastfeeding women, individuals with G6PD deficiency, and those under 18 years of age—should avoid using it.
Contraindications for methylene blue therapy include the use of two classes of drugs: monoamine oxidase inhibitors (MAOIs) and selective serotonin reuptake inhibitors (SSRIs), as well as G6PD deficiency. The latter, also known as favism, is a genetically determined condition caused by a deficiency of the enzyme glucose-6-phosphate dehydrogenase. This enzyme is essential for producing NADPH, which protects red blood cells from oxidative damage. Most people with G6PD deficiency are aware of their condition. In Poland, it is extremely rare, estimated to affect about 0.1% of the population, predominantly men, since they have only one X chromosome, while women have two. It is generally accepted that low doses (e.g., 0.5-2 mg/kg of body weight) are safe for humans, but it’s always advisable to consult a doctor or naturopath before starting methylene blue therapy.
FAQ
Is methylene blue safe?
Yes, pharmaceutical-grade methylene blue is used in medicine, including the treatment of certain health conditions. It is important to follow the directions and not to use it in an incompatible manner, especially with SSRI drugs or cosmetic preparations of unknown origin. Methylene blue is also contraindicated in people with glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency.
Can methylene blue be safely combined with dietary supplements?
Yes. Methylene blue does not have any specific interactions with common dietary supplements, such as ashwagandha, vitamin C, B vitamins, hyaluronic acid or minerals. However, if you plan to combine it with other substances, it’s worth consulting your doctor or nutritionist. It is important to be cautious if you are taking other medications, as methylene blue can affect the metabolism of certain substances, especially in large doses.
Is methylene blue effective when taken orally?
Yes, methylene blue can be effective when taken orally. It acts as a powerful antioxidant that can promote cell health and improve mitochondrial function, which has potential applications in the treatment of various neurological conditions. Methylene blue is gaining popularity in the medical and research communities for its neuroprotective properties, memory support and beneficial effects on processes related to energy production in cells. Oral intake of methylene blue is effective in specific therapeutic contexts and may offer a wide range of health benefits.
Can pregnant and breastfeeding women also take methylene blue?
No. Pregnant and breastfeeding women should avoid taking methylene blue unless absolutely recommended by a doctor. Methylene blue can cross the placenta and affect fetal development, as well as pass into breast milk, which carries potential risks for infants. Therefore, its use during this period requires extreme caution and careful assessment of risks and benefits. If necessary, always consult a doctor before using it during pregnancy or breastfeeding.
Is it better to take methylene blue before or after eating?
Methylene blue can be taken both on an empty stomach and after eating, but the choice depends on your tolerance and possible recommendations
Fasting: When taken on an empty stomach, it can increase absorption, which can be beneficial in some therapeutic applications. However, in sensitive individuals, it may cause stomach discomfort.
After eating: If nausea or other stomach problems occur, it is recommended to take methylene blue after a meal, which may help relieve them.
Can I combine methylene blue with skin supplements such as collagen, vitamin C or hyaluronic acid?
Yes, methylene blue can be used simultaneously with supplements that support skin health, such as collagen, vitamin C or hyaluronic acid. These substances have different mechanisms of action and can mutually support the skin’s regenerative and moisturizing processes. Vitamin C supports collagen production, hyaluronic acid improves skin hydration, and methylene blue can increase skin elasticity and delay the aging process. However, it’s worth remembering that each body may react differently, so it’s always a good idea to start with smaller doses and observe the skin’s reaction.
Are there any contraindications to using methylene blue with medications?
Methylene blue can interact with some medications and supplements. For example, people taking antidepressants from the monoamine oxidase inhibitor (MAO) group should avoid methylene blue, as it can affect serotonin levels and lead to potentially dangerous interactions. In addition, caution should be exercised for those using sleep medications or painkillers, which can increase the risk of side effects when using methylene blue.
Can I use methylene blue together with supplements for detoxification of the body?
Yes. There are no contraindications to using methylene blue at the same time as supplements to support detoxification of the body, but in such a case it is important to exercise caution. Detoxification of the body is a process that may require specific methods of support, and methylene blue is a specific compound whose effects can affect metabolism. It is always a good idea to tailor supplementation to the body’s individual needs.
What doses of methylene blue are safe?
Doses of methylene blue are strictly defined by manufacturers and health professionals. For cosmetic purposes (such as in creams), very small amounts of methylene blue are used, usually 5 drops per 50 ml of cream. For dietary supplements, the doses are smaller (about 10mg per 1 serving) and are intended to support the body. Methylene Blue’s toxicity starts at 7 mg per kilogram of body weight.
What side effects can occur when consuming methylene blue?
Consumption of methylene blue in large amounts (more than 7mg per kilogram of body weight) can lead to symptoms such as dizziness, headaches, nausea, and digestive problems. It can also cause urine to turn blue, which is a side effect but not dangerous. If you have any worrisome symptoms, discontinue use immediately and consult your doctor.
Can I combine methylene blue with supplements that support heart health, such as omega-3?
Yes, methylene blue can be safely used in combination with supplements containing omega-3 fatty acids, which support heart health and have anti-inflammatory effects. Omega-3 does not interact with methylene blue, and both ingredients can benefit overall health by improving circulation and skin health, among other things.
Does methylene blue affect the absorption of other supplements?
There is insufficient evidence that methylene blue affects the absorption of other dietary supplements. However, as with any active substance, it is important to use it as directed and avoid excessive doses, as this can affect the body’s metabolism. If you have any doubts about combining methylene blue with other supplements, it is best to consult a doctor or nutritionist.
What is methylene blue and how does it affect the skin?
Methylene blue is a chemical compound that has many uses in medicine, but discoveries in the field of dermatology have shown its beneficial effects on the skin. It works at the cellular level, extending the life of fibroblasts – the cells responsible for collagen production. This increases the skin’s elasticity and helps it retain water in its structure, resulting in smoother wrinkles and improved overall skin condition. Methylene blue also has an antioxidant effect, protecting the skin from the damaging effects of free radicals.
What are the benefits of using methylene blue in cosmetics?
- Slowing down the aging process – by increasing collagen production and improving skin texture.
- Moisturizing the skin – by improving the skin’s ability to retain water, making the skin firmer and more elastic.
- Protection against oxidative stress – by acting as a powerful antioxidant, it protects the skin from free radical damage.
- Improves skin density – regular use can cause
What is the best cream pH for methylene blue?
Methylene blue is most effective in formulas with a neutral or slightly acidic pH, in the range of 5.5-6.5. Too high a pH (alkaline) can affect the stability of the substance, reducing its effectiveness. Therefore, choosing the right pH of the cream is crucial to ensure optimal absorption of active ingredients and maximum benefit from methylene blue.
What proportions of methylene blue should be used in cosmetics?
In skin care cosmetics, it is recommended to add about 5 drops of methylene blue per 50 ml of cream. This is the optimal amount to achieve visible effects, such as improving skin firmness, without the risk of irritation. It is important not to exceed this dosage, as a higher amount can affect the texture and color of the cosmetic.
Is methylene blue safe to use on the skin?
Yes, methylene blue is considered safe for use on the skin when used in the correct proportions and according to the manufacturer’s recommendations. However, it is worth remembering that it can cause the skin to turn blue if used excessively, but this is a temporary effect that disappears after a few hours. If you have sensitive skin, it is worth conducting an allergy test by applying a small amount of the product to a small area of skin.
What effects can I notice after using methylene blue cream?
After regular use of methylene blue cream, you may notice:
- Smoothing of the skin – reducing the appearance of fine lines and wrinkles.
- Increased elasticity – the skin becomes firmer, tighter and more resilient.
- Improved hydration – skin looks fuller and more hydrated.
- Brighter and more radiant looking skin – the light reflecting effect on more resilient skin makes it look younger and healthier.
Is methylene blue cream suitable for all skin types?
Creams containing methylene blue are suitable for most skin types, including mature, dry or sensitive skin. However, those with very sensitive skin should consult a dermatologist before first use to ensure that the ingredient will be well tolerated. It is also recommended to perform an allergy test before full application.
How long do I need to use methylene blue cream to notice the first effects?
The first effects, such as better hydration and smoother skin, may be noticeable after just a few days of regular use. For more long-lasting and noticeable anti-aging effects, it is recommended to use the cream for at least 3-4 weeks. Regularity is the key to success when it comes to skin care.
Can methylene blue be used in combination with other active ingredients in skin care?
Methylene blue is safe to use in combination with other popular active ingredients, such as hyaluronic acid, vitamin C or retinol. However, it is a good idea to avoid mixing it with substances with strong alkaline action, which can affect its stability and effectiveness. When in doubt, it is always a good idea to consult a dermatologist or skin care specialist.
Can methylene blue stain the skin?
Pure methylene blue can sometimes leave a slight bluish tint on the skin, especially if used in excess. However, this is a temporary effect that disappears after a few hours. To avoid this effect, use it in the proper proportions and avoid contact with clothing or other surfaces that can easily absorb the dye.
Can it be diluted with water or juice?
Methylene blue is most often available as a concentrated solution. It is best to dilute it in water (preferably boiled or distilled) or juice before consumption. It can be taken both on an empty stomach and after a meal. If nausea occurs, it is better to consume after eating.
What doses in microdosing, and what doses in therapy?
Use of low doses: In research or experimental applications (e.g., mitochondrial support), doses are usually very low and can range from 0.5 to 10 mg per serving or for a whole day. The therapeutic dose depends on the indication and is determined by the physician. It can be about 1-2 mg/kg body weight in diluted form.
How long does methylene blue last?
The effect can be felt as early as 30-60 minutes after administration and lasts for several hours. Antioxidant effects and effects at the cellular level, such as mitochondrial support, can be longer and depend on the dose and frequency of use. The half-life in the body is about 5 hours. This means that after this time half of the dose is removed from the body. However, it can linger in the tissues for a longer time, and its metabolites (such as leucoblue) can still be active for several hours. The effect of tinting the urine blue or green can last 12-24 hours after taking it, which is a natural phenomenon.
Who should not use methylene blue?
Methylene blue is contraindicated in people with a deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD). This enzyme defect increases the risk of serious side effects because the body is unable to process methylene blue efficiently, which can lead to the dangerous breakdown of red blood cells (hemolysis). Why is G6PD important in the context of methylene blue? Function of G6PD: This enzyme protects red blood cells from oxidative stress. This substance can cause an increase in oxidative stress, and people with G6PD deficiency do not have sufficient enzymatic protection. This leads to hemolysis, the breakdown of red blood cells. Methylene blue is effective in many applications, but for people with G6PD deficiency it is potentially dangerous and requires an alternative therapeutic approach.